The effects of long-term Aloe vera ingestion on age-related diseases were investigated using male specific pathogen-free (SPF) Fischer 344 rats. This study demonstrates that life-long Aloe vera ingestion produced neither harmful effects nor deleterious changes. In addition, Aloe vera ingestion appeared to be associated with some beneficial effects on age-related diseases.

Aloe vera supports a substantial global trade yet its wild origins, and explanations for its popularity
over 500 related Aloe species in one of the world’s largest succulent groups, have remained uncertain. We
developed an explicit phylogenetic framework to explore links between the rich traditions of medicinal use and leaf
succulence in aloes.

Barbados aloe ( Aloe vera (L.) Burm. F.) has traditionally been used for healing in natural medicine. However, aloe is now attracting great interest in the global market due to its bioactive chemicals which are extracted from the leaves and used in industrial preparations for pharmaceutical, cosmetic, and food products.